This episode starts with Boden and his men rushing to a fire, they arrive on the scene of a factory, the employees are stumbling out of the building and gasping for air. Boden learns that a pipe cracked and the building is filling with a dangerous chemical gas. Two men are trapped on the roof, Severide and Casey begin scaling a ladder to the roof to rescue them. There is a huge explosion in the building, but they manage to hang on to the ladder. They make it to the top of the roof and help down the two men that are trapped. Back-up arrives in hazmat suit to put out the chemical fire, meanwhile they are trying to load up all of the employees into the ambulances.
Jay finds a strange girl in the apartment named Melanie, she spent the night with Will. After Melanie leaves, Jay asks Will why he is showing up late for work on his first day. Will laughs that it is his first day and his last day and he has decided to leave town. Jay begs him to give it a couple weeks and see something through for once instead of bailing.
At the hospital, April receives a phone call warning her that there are 30 people coming in with hydrous-ammonia poisoning. Will shows up at the hospital just in time, he meets the other doctor working the shift with him, Hannah, and then they are slammed with gas victims. Severide and Casey begin wheeling in the gas victims and the waiting room is already filled with flu patients. Chaos ensues, and a man with the flu climbs up on a chair and starts screaming that the “Americans are going to die,” and he shouts that it is“worse then Ebola.” and then he pulls a pin on a grenade. Severide tackles him and the grenade goes off, there is a huge explosion in the middle of the waiting room.
After the smoke clears, some of the people that were injured try to run out of the hospital, Boden and the firefighters outside stop them and send them back in the hospital. They are under lock down until they know what kind of warfare they are dealing with, the bomber said that it was “worse than Ebola.” Will begins taking care of the injured people in the waiting room, he finds Severide face down on the floor and unconscious. His pulse is weak, he tells Mills to give him a black tag. Mills shouts that they are not giving up on Severide, and calls for a gurney. Jay arrives outside of the hospital and calls Will, he explains to Jay that the terrorist said the grenade was “worse then Ebola” Jay says that he is going to look in to it and find out what they are dealing with.
Meanwhile, Dawson finds a man with a bone sticking out of his stomach, she thinks that it is his rib. Will investigates and says that it is actually one of the dead guys laying on the floor’s arm bones.
In an operating room Hannah is working on Severide, he is having a dream about Shay while he is unconscious. Suddenly he flatlines and Hannah begins scrambling and shouting for help. Mills and Brett rush to Hannah’s side to help with Severide, Mills runs a chest tube through Severide and he stabilizes. Hannah says they aren’t out of the woods yet, they need to make sure that none of Severide's other injuries could be life-threatening.
April finds a little girl named Ruby in the waiting room, she was there with the flu before the terrorist grenade went off, she tries to comfort her. A woman from disease control named Diane arrives at the hospital in a hazmat suit, she heads over to where the grenade exploded to determine whether or not they were infected with some sort of virus.
Meanwhile, Casey notices that there is a fire in the ceiling and it is spreading. He and Otis investigate, but the hospital is sealed off and all of their fire extinguishers and equipment are outside. Boden and his men are trying to figure out how they are going to get the fire extinguishers inside, Cruz and Rice volunteer to risk getting contaminated and go inside. They head inside with the extinguishers and get to work on the fire.
A woman arrives at the hospital and is frantic, she demands to get inside. She says that her son Amin left a note and said that he was going to the hospital to “finish his quest.” The woman and her husband are taken to the tent where the Chicago PD are set up next to the hospital. Jay sits down with Amin’s parents, they are in shock, they said that he was a smart boy and always helpful. Amin’s dad confesses that he worked at BHO Labs and they were studying infectious diseases.
Inside the hospital they get the fire put out, but one of the patients is growing restless, he argues with Casey about when he will be released. Casey shouts at him to sit down and stop being disruptive and the guy attacks him and attempts to hit him over the head with a board. April jumps on the guys back and gives him a shot that puts him to sleep.
Will gets a phone call from Jay, he learns that Amin was working with a biological disease called Marberg and he infected himself with it before he blew himself up with the grenade. The woman from disease control says that there is a chance they weren’t infected, she has to run some tests and see if the disease had germinated yet. If it had and was contagious, then they will all come down with a hemorrhaging fever in a matter of hours. On the bright side, in the operating room they get the rest of the shrapnel out of Severide and tie off his arteries, he is going to pull through.
Diane takes a sample of Herrmann’s blood to run a test on it, she says that it will determine whether or not they were infected with the disease. A few moments later Diane heads in to the waiting room and announces that they have all been infected with the flu, but the Marberg disease did not have time to incubate, so they are all going to be fine. Will tells the nurses to open up the ER, they are no longer under quarantine.
Later, everyone celebrates at Molly's, where Boden delivers a thankful speech for Chicago Med's incredible work today. Goodwin counters with a statement of her own and echoes his sentiment, reminding that firefighters and the hospital must always work in concert, they rely on each other's professionalism and skill.
Brett says that she is going to miss Mills and she isn’t ready to meet his replacement.
Severide wakes up in the hospital and April is standing over him and watching him. She admits that she was scared, Severide doesn’t remember what happened.
The intensity of the day seems to magnetize Dawson and Casey, and they end up in a spontaneous moment of passion. Is it just a reaction to the events in the hospital, or are they ready to reenter a relationship? They decide to ignore the big questions and just dive in, their attraction too fierce to resist.
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